We investigated the link between plasma omega-3 levels and the risk of heart failure (HF) in a large UK cohort study. Our analysis revealed that higher omega-3 levels were associated with a 21% lower chance of developing HF over nearly 14 years.
For individuals already diagnosed with HF, elevated omega-3 levels corresponded to about a 50% reduction in the risk of overall and cardiovascular mortality. These results suggest that boosting omega-3 intake through diet or supplements may help prevent HF and increase longevity for those already facing heart challenges.
Read More
9
Omega-3 reduces cardiovascular risk
Cardiovascular Outcomes With Icosapent Ethyl by Baseline Low-Density Lipoprotein Cholesterol: A Secondary Analysis of the REDUCE-IT Randomized Trial.
We observed the effects of icosapent ethyl on heart health in a significant clinical trial involving statin-treated patients at high risk for cardiovascular events. This post hoc analysis revealed that icosapent ethyl reduced major cardiovascular issues, regardless of whether patients had low-density lipoprotein cholesterol (LDL-C) levels below or above 55 mg/dL.
Notably, those with optimal LDL-C control still benefited from the treatment, showing that this fish oil derivative can be effective in managing heart risks for many patients.
Read More
8
Eicosapentaenoic acid reduces arrhythmia
Eicosapentaenoic acid prevents atrial electrocardiographic impairments and atrial fibrillation in high fat diet mice.
We explored the impact of eicosapentaenoic acid (EPA) on heart health by studying mice on a high-fat diet. Those supplemented with EPA showed a significant reduction in atrial fibrillation compared to those without. While 100% of the high-fat diet mice developed atrial fibrillation, only 50% of those receiving EPA did, and their episodes were shorter.
Our findings suggest that including EPA in the diet can help improve heart function and reduce irregular heart rhythms linked to high-fat diets.
Read More
Most Useful Reviews
9
Cardiovascular remedy
33 people found this helpful
This "Mega" omega fish oil is superb! It helps reduce cholesterol concentrations, acts as a preventive measure against cardiovascular disease, and has shown potential in cancer prevention. Omega 3 aids in skin conditions, allergies, and arthritis, often providing relief in just days. It's crucial for brain function and normal embryo development. I take 3-4 capsules daily with meals.
Read More
9
Essential nutrient
4 people found this helpful
This is my favourite omega. The triglyceride form enhances absorption, aiding the cardiovascular system, brain function, and joint health. It’s simpler to take capsules than consume fish regularly. I integrate it into my daily routine, believing it’s essential for health.
Read More
9
Lowers heart risks
1 people found this helpful
Omega-3 lowers blood pressure and triglycerides, reducing blockage, atherosclerosis, and risks of heart attack or stroke. It also decreases the likelihood of sudden death from heart disease.
We observed the effects of icosapent ethyl on heart health in a significant clinical trial involving statin-treated patients at high risk for cardiovascular events. This post hoc analysis revealed that icosapent ethyl reduced major cardiovascular issues, regardless of whether patients had low-density lipoprotein cholesterol (LDL-C) levels below or above 55 mg/dL.
Notably, those with optimal LDL-C control still benefited from the treatment, showing that this fish oil derivative can be effective in managing heart risks for many patients.
Read More
9
Omega-3 improves heart function
The Optimal Dosage and Duration of ω-3 PUFA Supplementation in Heart Failure Management: Evidence from a Network Meta-Analysis.
We assessed how omega-3 fatty acids (PUFAs) can support heart failure management through a thorough network meta-analysis of 14 studies with nearly 9,100 participants.
Our findings revealed that high doses (2,000-4,000 mg/day) taken for at least one year significantly improved heart function, particularly the left ventricular ejection fraction and peak oxygen consumption.
However, lower doses and shorter durations were not effective, and we found no major differences in safety measures like dropout rates or overall mortality between those taking omega-3 and those who were not.
Read More
9
Omega-3 levels reduce heart failure
Association of Plasma Omega-3 Levels With Incident Heart Failure and Related Mortalities.
We investigated the link between plasma omega-3 levels and the risk of heart failure (HF) in a large UK cohort study. Our analysis revealed that higher omega-3 levels were associated with a 21% lower chance of developing HF over nearly 14 years.
For individuals already diagnosed with HF, elevated omega-3 levels corresponded to about a 50% reduction in the risk of overall and cardiovascular mortality. These results suggest that boosting omega-3 intake through diet or supplements may help prevent HF and increase longevity for those already facing heart challenges.
Read More
9
Krill oil may improve heart health
Antarctic Krill Oil Supplementation Attenuates Hypercholesterolemia, Fatty Liver, and Oxidative Stress in Diet-Induced Obese Mice.
We delved into how Antarctic krill oil, rich in eicosapentaenoic acid (EPA), can influence cardiovascular health, specifically in the context of obesity. Our focus centered on its effects in mice fed a high-fat diet, which typically leads to increased cholesterol levels and oxidative stress—conditions that can heighten cardiovascular disease risk.
Through our research methods, including molecular docking and analysis of liver histology, we discovered that Antarctic krill oil appears to play a beneficial role in combating these adverse effects. We observed that the oil reduced oxidative stress and fat accumulation in these obese mice. This was associated with improved metabolic parameters that contribute to heart health, primarily through its action on molecules involved in cholesterol metabolism.
Notably, we found that krill oil helped lower the levels of harmful low-density lipoprotein cholesterol and activated pathways that support good cholesterol management in the body. These findings suggest that incorporating Antarctic krill oil, with its high EPA content, might be a promising strategy for addressing obesity-related cardiovascular issues.
Overall, our study points to the potential of eicosapentaenoic acid from krill oil as a natural approach to improving heart health, particularly for those struggling with obesity and its challenges.
Read More
8
Omega-3s are safer for hearts
EPA and DHA acylcarnitines are less cardiotoxic than are saturated and monounsaturated long-chain acylcarnitines.
This study examined how different fatty acids affect heart health, particularly focusing on long-chain acylcarnitines. We found that saturated and monounsaturated acylcarnitines, especially one type called trans-elaidoylcarnitine, can significantly harm heart function and cell viability.
On the other hand, omega-3 derived acylcarnitines like eicosapentaenoylcarnitine and docosahexaenoylcarnitine showed minimal negative effects. In fact, they did not impair heart function or cell viability, suggesting that omega-3 fish oil might be a safer option for people with heart issues compared to other fatty acid sources.
This "Mega" omega fish oil is superb! It helps reduce cholesterol concentrations, acts as a preventive measure against cardiovascular disease, and has shown potential in cancer prevention. Omega 3 aids in skin conditions, allergies, and arthritis, often providing relief in just days. It's crucial for brain function and normal embryo development. I take 3-4 capsules daily with meals.
Read More
9
Essential nutrient
4 people found this helpful
This is my favourite omega. The triglyceride form enhances absorption, aiding the cardiovascular system, brain function, and joint health. It’s simpler to take capsules than consume fish regularly. I integrate it into my daily routine, believing it’s essential for health.
Read More
9
Lowers heart risks
1 people found this helpful
Omega-3 lowers blood pressure and triglycerides, reducing blockage, atherosclerosis, and risks of heart attack or stroke. It also decreases the likelihood of sudden death from heart disease.
Read More
9
Winter health benefits
1 people found this helpful
Super fish oil! I began using this product for my family last summer. The results were quick; winter passed without illness, and my grandmother, who turns 80 this year, looks and feels amazing. If you weigh more, like me (103 kg – athlete), take two capsules in the morning and evening!
Read More
9
Cardiovascular system support
This product offers excellent value for money. Omega-3 is essential for the nervous and cardiovascular systems, enhancing heart health and preventing gastric issues. I recommend it to all my friends; the price is effective for such benefits.
Cardiovascular disease (CVD) is a broad term that encompasses a range of heart and blood vessel disorders. This can include conditions such as coronary artery disease, which leads to heart attacks; cerebrovascular disease that results in strokes; and peripheral artery disease affecting blood flow to the limbs. The key risk factors for CVD often include high blood pressure, high cholesterol, obesity, smoking, a sedentary lifestyle, and diabetes. By identifying and managing these risk factors, individuals can significantly reduce their likelihood of developing cardiovascular problems.
Prevention and treatment strategies often involve lifestyle modifications such as adopting a heart-healthy diet rich in fruits, vegetables, whole grains, and lean proteins, alongside engaging in regular physical activity. In some cases, medications might be necessary to control blood pressure or cholesterol levels. Regular check-ups with a healthcare provider are essential for monitoring heart health, especially for individuals with a family history of CVD. Understanding the signs and symptoms of cardiovascular issues—like chest pain, shortness of breath, or fatigue—can help in seeking timely medical attention, ultimately leading to better outcomes.
Omega-3 fish oil is a nutritional supplement derived from the fatty tissues of fish, particularly fatty fish like salmon, mackerel, and sardines. It is rich in omega-3 fatty acids, which are essential fats that the body cannot produce on its own. The most significant types of omega-3s found in fish oil are eicosapentaenoic acid (EPA) and docosahexaenoic acid (DHA), both of which are known for their numerous health benefits. These include reducing inflammation, supporting heart health, and promoting brain function.
Incorporating omega-3 fish oil into your diet can be beneficial if you don’t consume enough fish regularly. Many health experts recommend oily fish as a part of a balanced diet due to their high omega-3 content. For those who find it difficult to include fish in their meals, fish oil supplements can offer a convenient alternative, providing the same essential fatty acids in concentrated form. However, it’s essential to choose high-quality supplements that are third-party tested for purity and potency to avoid contaminants such as heavy metals or other toxins that can impact health.
Omega-3 fish oil has long been touted for its potential cardiovascular benefits, and numerous studies support the notion that it can be helpful in managing overall heart health. Rich in EPA and DHA, the primary active components in fish oil, omega-3 fatty acids are known to reduce triglyceride levels, lower blood pressure, and may even decrease the risk of arrhythmias. Some research suggests that regular consumption of omega-3s can lead to a reduced risk of heart disease and stroke by improving vascular health and reducing inflammation in the body.
However, it's essential to approach this topic with a balanced perspective. While omega-3 supplements can be beneficial, they should not be seen as a standalone solution for cardiovascular disease. Incorporating omega-3s through diet—such as fatty fish like salmon, sardines, and mackerel—is preferable to relying solely on supplements. Moreover, if you're considering adding fish oil supplements to your routine, it's advisable to consult with a healthcare provider to ensure they fit within your complete cardiovascular health strategy, which should also include a nutritious diet, regular exercise, and other heart-healthy lifestyle choices.
Based on user reviews, the time it takes to see results from taking omega-3 supplements for cardiovascular health can vary. Many users report experiencing noticeable improvements in their overall well-being and cardiovascular function relatively quickly. For instance, one user mentioned immediate positive effects, indicating their grandmother felt amazing after starting the supplement last summer (Read Review). Additionally, another user noted reduced blood pressure and a lower risk of cardiovascular issues after consistent use, suggesting results within a short time frame (Read Review).
Other users shared similar sentiments, discussing improvements in heart health and cholesterol levels within days or weeks of starting the supplement (Read Review; Read Review). Though individual experiences may vary depending on factors like dosage and overall health, many users seem to echo the sentiment that benefits can be apparent relatively swiftly after initiating omega-3 supplementation.
The role of omega-3 fatty acids, particularly eicosapentaenoic acid (EPA) and docosahexaenoic acid (DHA), in supporting cardiovascular health is backed by a growing body of scientific research. Numerous studies have demonstrated that these fatty acids can positively influence various cardiovascular risk factors. For instance, higher levels of omega-3 fatty acids have been associated with a reduced risk of cardiovascular events and improved lipid profiles, including increased high-density lipoprotein (HDL) cholesterol and lowered triglyceride levels [27]. Additionally, clinical trials have shown that supplementation with EPA can significantly reduce major cardiovascular risks among high-risk patients, regardless of their baseline low-density lipoprotein (LDL) cholesterol levels [5].
Research also highlights specific beneficial effects of omega-3 fatty acids on heart function, inflammation, and arrhythmia management. Long-term high-dose omega-3 supplementation has been linked to improved heart function in patients with heart failure [7], while omega-3 intake may reduce inflammation and lower rates of atrial fibrillation [21][9]. Overall, the evidence suggests that incorporating omega-3 fatty acids into the diet or as supplements provides a viable strategy for enhancing heart health, especially in those with existing cardiovascular conditions.
Users have reported a variety of improvements in their symptoms after taking omega-3 supplements, particularly concerning cardiovascular health. Many individuals mentioned a noticeable reduction in cholesterol levels and blood pressure, often highlighting the supplement's role in decreasing the risk of heart disease and related issues (Read Review, Read Review). For instance, one user shared their grandmother's remarkable health transformation after beginning the supplement, noting that she looks and feels fantastic after a winter season without illness (Read Review).
Beyond cardiovascular benefits, users have also reported improvements in skin health and overall energy levels. Many have claimed that omega-3 supplementation has led to clearer, more vibrant skin, while others have experienced boosts in mood and energy (Read Review, Read Review). While these anecdotal experiences are promising and suggest a positive correlation between omega-3 intake and various health improvements, it's important to note that individual results can differ based on a multitude of factors, including dosage and personal health conditions.
Based on user reviews, many individuals have reported positive experiences when combining omega-3 supplements with other health supplements for managing cardiovascular disease. Users often highlight that omega-3s effectively complement their overall supplement routine, enhancing heart health while also providing additional benefits such as improved skin condition and joint support (Read Review, Read Review). For instance, one user noted that integrating omega-3 into their daily regimen feels essential for health and supports various bodily functions beyond just cardiovascular health (Read Review).
Additionally, users emphasize that omega-3 supplements can be taken alongside other daily supplements without adverse effects, making them a versatile addition to any health plan (Read Review, Read Review). The compatibility of omega-3 with other supplements indicates a favorable consensus among users regarding its role in promoting cardiovascular wellness alongside a multi-faceted approach to health management. Overall, those who shared their experiences suggest a combination of supplements can be beneficial, particularly when omega-3 is included for its specific cardiovascular advantages and overall well-being.
When it comes to optimizing cardiovascular health through omega-3 fish oil supplementation, research suggests that high doses are most effective. Particularly, a meta-analysis of 14 studies with nearly 9,100 participants indicated that dosages ranging from 2,000 to 4,000 mg of omega-3 fatty acids per day, sustained over at least one year, significantly improved heart function markers such as left ventricular ejection fraction and peak oxygen consumption [7]. It's noteworthy that lower doses and shorter treatment durations were not found to yield similar benefits, making the higher dosage particularly relevant for individuals managing heart failure or looking to enhance overall cardiovascular performance.
Additionally, the research emphasizes the importance of long-term supplementation, as the benefits observed require consistent intake over time. It's crucial for individuals who are considering omega-3 oil for heart health to consult healthcare professionals to tailor the dosage and duration specific to their health status and genetic background, as factors like individual response to lipid profiles and potential interactions with other treatments can influence outcomes [2].
9
Winter health benefits
1 people found this helpful
Super fish oil! I began using this product for my family last summer. The results were quick; winter passed without illness, and my grandmother, who turns 80 this year, looks and feels amazing. If you weigh more, like me (103 kg – athlete), take two capsules in the morning and evening!
9
Heart disease risk reduction
42 people found this helpful
I noticed reduced blood pressure and a lower risk of cardiovascular disease. I'm particularly grateful for the decrease in heart attack risks. Please give me a like! May peace be upon you and your family.
9
Cardiovascular remedy
33 people found this helpful
This "Mega" omega fish oil is superb! It helps reduce cholesterol concentrations, acts as a preventive measure against cardiovascular disease, and has shown potential in cancer prevention. Omega 3 aids in skin conditions, allergies, and arthritis, often providing relief in just days. It's crucial for brain function and normal embryo development. I take 3-4 capsules daily with meals.
7.5
Regulates blood lipids
1 people found this helpful
This fish oil is cost-effective and has worked well for my mother, who has normal blood lipids thanks to its consumption. It's beneficial for those with cardiovascular disease, helping to manage blood lipids and reduce the risk of coronary heart disease.
9
Lowers heart risks
1 people found this helpful
Omega-3 lowers blood pressure and triglycerides, reducing blockage, atherosclerosis, and risks of heart attack or stroke. It also decreases the likelihood of sudden death from heart disease.
7.5
Boosts cardiovascular health
2 people found this helpful
The positive effects of Natrol Fish Oil are evident: my skin peeling is gone, and I feel more energetic throughout the day. I hope it also benefits my cardiovascular system, as the packaging claims.
9
Supports heart health
3 people found this helpful
My favourite omega-3! It effectively supports my cardiovascular system, and my hand dry skin has improved significantly.
9
Essential nutrient
4 people found this helpful
This is my favourite omega. The triglyceride form enhances absorption, aiding the cardiovascular system, brain function, and joint health. It’s simpler to take capsules than consume fish regularly. I integrate it into my daily routine, believing it’s essential for health.
9
Omega-3 benefits
I take this for prevention. The importance of Omega-3 cannot be overstated; it helps to cleanse blood vessels of "bad" cholesterol, reducing the risk of cardiovascular disease. It improves blood viscosity, normalises blood pressure, and raises "good" cholesterol levels. Omega-3 also boosts serotonin production, enhancing mood and immunity. As our bodies cannot produce Omega-3, supplements are vital. I take two capsules at lunch, which curb my hunger. I suggest consulting a doctor for treatment dosages, and remember potential contraindications.
7.5
Transparent dosage
5 people found this helpful
Natrol offers excellent fish oil with a clear dosage of 1000mg per capsule. It's convenient to take, and I appreciate its compatibility with other supplements. I recommend checking dosage information when choosing omega products for cardiovascular health.
9
Reduces cardiovascular risk
3 people found this helpful
This is one of the best products I’ve used, containing high-quality ingredients that evidently reduce the risk of cardiovascular disease and cleanse the body of toxins. I've heard positive results since I began using this brand. Suitable for all ages, it offers multiple benefits.
8
32% eligible for EPA supplementation
Eligibility for marine omega-3 fatty acid supplementation after acute coronary syndromes.
We aimed to explore the use of eicosapentaenoic acid (EPA), a type of marine omega-3 fatty acid, in lowering cardiovascular risk among patients recovering from acute coronary syndromes (ACS). In our study, we analyzed data from a Swiss group of 2,643 patients who were hospitalized for ACS.
One year after their first heart event, we found that 32% of these patients were eligible for EPA supplementation, particularly those with elevated triglyceride levels. Notably, eligibility was higher among younger individuals, smokers, diabetics, hypertensive patients, and those who were obese.
We also looked into potential ways to enhance this eligibility through additional lipid-lowering therapies, such as statins and ezetimibe. However, despite these adjustments in treatment strategies, we observed only a slight reduction in the percentage of patients who met the criteria for EPA supplementation.
This finding suggests that there's a significant opportunity to reduce cardiovascular risks in those who qualify for EPA, especially among patients with hypertriglyceridemia. It becomes clear that integrating omega-3 fatty acids into treatment plans could be beneficial for many patients in this high-risk group.
9
Omega-3 reduces cardiovascular risk
Cardiovascular Outcomes With Icosapent Ethyl by Baseline Low-Density Lipoprotein Cholesterol: A Secondary Analysis of the REDUCE-IT Randomized Trial.
We observed the effects of icosapent ethyl on heart health in a significant clinical trial involving statin-treated patients at high risk for cardiovascular events. This post hoc analysis revealed that icosapent ethyl reduced major cardiovascular issues, regardless of whether patients had low-density lipoprotein cholesterol (LDL-C) levels below or above 55 mg/dL.
Notably, those with optimal LDL-C control still benefited from the treatment, showing that this fish oil derivative can be effective in managing heart risks for many patients.
9
Omega-3 improves heart function
The Optimal Dosage and Duration of ω-3 PUFA Supplementation in Heart Failure Management: Evidence from a Network Meta-Analysis.
We assessed how omega-3 fatty acids (PUFAs) can support heart failure management through a thorough network meta-analysis of 14 studies with nearly 9,100 participants.
Our findings revealed that high doses (2,000-4,000 mg/day) taken for at least one year significantly improved heart function, particularly the left ventricular ejection fraction and peak oxygen consumption.
However, lower doses and shorter durations were not effective, and we found no major differences in safety measures like dropout rates or overall mortality between those taking omega-3 and those who were not.
8
Inflammation response to omega-3s
Associations between omega-3 fatty acid-derived lipid mediators and markers of inflammation in older subjects with low-grade chronic inflammation.
We explored the potential connection between eicosapentaenoic acid (EPA), which is an omega-3 fatty acid, and its role in reducing inflammation related to cardiovascular disease (CVD) in older adults. In our study, we measured the plasma levels of various omega-3 fatty acids and their specialized pro-resolving lipid mediators (SPMs) in a group of 21 older participants who exhibited low-grade chronic inflammation.
The findings were intriguing. We observed that higher levels of docosahexaenoic acid (DHA) were linked to lower concentrations of several inflammatory markers, including interleukin-6 (IL-6) and tumor necrosis factor-α (TNF-α). Additionally, certain SPMs derived from EPA and DHA were also associated with reductions in inflammation levels, suggesting that these omega-3-derived substances might support the body's natural ability to resolve inflammation.
However, while the association between omega-3 fatty acids and inflammation was apparent, our study did not isolate the effects of EPA alone. This means we cannot definitively conclude the unique impact of eicosapentaenoic acid on cardiovascular health.
Overall, this research sheds light on how dietary intake of omega-3 fatty acids, particularly from sources rich in DHA and EPA, may benefit inflammation regulation—an important aspect of cardiovascular well-being.
8
Omega-3s improve cardiovascular health
Recent developments, challenges, and prospects of dietary omega-3 PUFA-fortified foods: Focusing on their effects on cardiovascular diseases.
We examined the effects of dietary omega-3 polyunsaturated fatty acids (Dω-3 PUFAs) on cardiovascular diseases (CVDs) through recent clinical trials and food fortification trends.
Evidence suggests that these beneficial fatty acids can lower heart disease risk, improve blood pressure, and enhance lipid profiles.
While advancements in fortifying foods with Dω-3 PUFAs show promise, there's still a need for more research to maximize their health benefits and ensure better protection against CVDs.
4
Genetics influence omega-3 effectiveness
The influence of FADS1 and ELOVL2 genetic polymorphisms on polyunsaturated fatty acid composition in response to fish oil supplementation.
We aimed to evaluate how genetic factors influence the effectiveness of fish oil supplementation on fatty acid profiles in healthy individuals.
In this study, 86 adults participated in a 4-week fish oil program, and their lipid profiles were assessed before and after the supplementation.
We found that genetic variations, specifically in the FADS1 and ELOVL2 genes, might affect how well the body utilizes omega-3 fatty acids.
This highlights the potential for personalized nutrition to enhance cardiovascular health.
References
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Medoro A, Graziano F, Cardinale G, Voccola S, Zotti T, et al. The influence of FADS1 and ELOVL2 genetic polymorphisms on polyunsaturated fatty acid composition in response to fish oil supplementation. Lipids Health Dis. 2025;24:102. doi:10.1186/s12944-025-02513-w
Horii K, Ono K, Sumi T, Higashihara M, Zaima N, et al. Eicosapentaenoic acid prevents atrial electrocardiographic impairments and atrial fibrillation in high fat diet mice. J Physiol Sci. 2025;75:100014. doi:10.1016/j.jphyss.2025.100014
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Aggarwal R, Bhatt DL, Steg PG, Miller M, Brinton EA, et al. Cardiovascular Outcomes With Icosapent Ethyl by Baseline Low-Density Lipoprotein Cholesterol: A Secondary Analysis of the REDUCE-IT Randomized Trial. J Am Heart Assoc. 2025;14:e038656. doi:10.1161/JAHA.124.038656
Mao Q, Tian X, Wang X, Xu H, Zhang Y, et al. Global burden of cardiovascular diseases attributable to diet low in seafood omega-3 fatty acids from 1990~2021 and forecasting the future trends: A population-based study. PLoS One. 2025;20:e0316767. doi:10.1371/journal.pone.0316767
Tseng PT, Zeng BY, Hsu CW, Liang CS, Stubbs B, et al. The Optimal Dosage and Duration of ω-3 PUFA Supplementation in Heart Failure Management: Evidence from a Network Meta-Analysis. Adv Nutr. 2025;16:100366. doi:10.1016/j.advnut.2025.100366
Hemmati R, Bahrami Zanjanbar D, Shishesaz MI, Soleimani A, Yari T. The impact of Omega-3 supplementation on arrhythmia reduction in acute coronary syndrome patients: a randomized clinical trial. J Complement Integr Med. 2025;22:173. doi:10.1515/jcim-2024-0427
Wang Y, Wu G, Wang Y, Rehman A, Yu L, et al. Recent developments, challenges, and prospects of dietary omega-3 PUFA-fortified foods: Focusing on their effects on cardiovascular diseases. Food Chem. 2025;470:142498. doi:10.1016/j.foodchem.2024.142498
Dong S, Wang Y, Bian J, Chen H, Dong J, et al. The effect of omega-3 Polyunsaturated Fatty Acid (PUFA) prescription preparations on the prevention of clinical cardiovascular disease: a meta-analysis of RCTs. Nutr J. 2024;23:157. doi:10.1186/s12937-024-01051-y
Jawad MA, O'Keefe JH, Tintle N, O'Keefe EL, Franco WG, et al. Association of Plasma Omega-3 Levels With Incident Heart Failure and Related Mortalities. Mayo Clin Proc. 2024;99:1895. doi:10.1016/j.mayocp.2024.08.007
Brosolo G, Da Porto A, Marcante S, Capilupi F, Bertin N, et al. The role for ω-3 polyunsaturated and short chain fatty acids in hypertension: An updated view on the interaction with gut microbiota. Eur J Pharmacol. 2024;985:177107. doi:10.1016/j.ejphar.2024.177107
Lee YQ, Tan KH, Chong MF. Biomarkers of PUFA and cardiovascular risk factors and events in healthy Asian populations: a systematic review. Br J Nutr. 2024;132:1474. doi:10.1017/S0007114524002708
Li J, Nan W, Huang X, Meng H, Wang S, et al. Eicosapentaenoic acid induces macrophage Mox polarization to prevent diabetic cardiomyopathy. EMBO Rep. 2024;25:5507. doi:10.1038/s44319-024-00271-x
Li ZH, Song WQ, Qiu CS, Li HM, Tang XL, et al. Fish oil supplementation, genetic susceptibility and risk of new-onset hypertension. Prev Med. 2024;189:108152. doi:10.1016/j.ypmed.2024.108152
Hamaya R, Cook NR, Sesso HD, Buring JE, Manson JE. A Bayesian Analysis of the VITAL Trial: Effects of Omega-3 Fatty Acid Supplementation on Cardiovascular Events. Am J Clin Nutr. 2025. doi:10.1016/j.ajcnut.2025.02.028
Liboriussen C, Nygaard L, Jensen JD, Schmidt EB, Glerup RI, et al. Low Plasma Marine N-3 Polyunsaturated Fatty Acids are Associated with Increased Risk of Cardiovascular Events in Patients Treated with Maintenance Hemodialysis. J Ren Nutr. 2025. doi:10.1053/j.jrn.2025.02.001
Yunoki K, Matsumi H, Miyoshi T, Kubo M, Hata Y, et al. Clinical Significance of Serum Omega-3 Fatty Acids on Endothelial Function in Patients with Coronary Artery Disease Under Statin Therapy. J Cardiovasc Dev Dis. 2025;12. doi:10.3390/jcdd12020060
Patil T, Gregory M, Savona N, Jarmukli N, Leonard CE. Evaluating the Real-World Safety of Icosapent Ethyl Versus Omega-3 Polyunsaturated Fatty Acid in Nationwide US Veterans Cohort: Examining Atrial Fibrillation and Bleeding Endpoints. Clin Drug Investig. 2025;45:69. doi:10.1007/s40261-024-01417-4
Kim JY, Kong SYJ, Jung E, Cho YS. Omega-3 Fatty Acids as Potential Predictors of Sudden Cardiac Death and Cardiovascular Mortality: A Systematic Review and Meta-Analysis. J Clin Med. 2024;14. doi:10.3390/jcm14010026
Lamon-Fava S. Associations between omega-3 fatty acid-derived lipid mediators and markers of inflammation in older subjects with low-grade chronic inflammation. Prostaglandins Other Lipid Mediat. 2025;176:106948. doi:10.1016/j.prostaglandins.2025.106948
Fukuda T, Nakajima T, Hasegawa T, Amano H, Arikawa T, et al. Relationship Between Serum ω-3 Polyunsaturated Fatty Acid Concentration and Fatty Acid Fraction of Epicardial Adipose Tissue in Patients With Cardiovascular Disease. Cureus. 2024;16:e73417. doi:10.7759/cureus.73417
O'Keefe EL, O'Keefe JH, Abuissa H, Metzinger M, Murray E, et al. Omega-3 and Risk of atrial fibrillation: Vagally-mediated double-edged sword. Prog Cardiovasc Dis. 2024. doi:10.1016/j.pcad.2024.11.003
Choi JH, Park SE, Kim S. Antarctic Krill Oil Supplementation Attenuates Hypercholesterolemia, Fatty Liver, and Oxidative Stress in Diet-Induced Obese Mice. Nutrients. 2024;16. doi:10.3390/nu16213614
So J, Yao JH, Magadmi R, Matthan NR, Lamon-Fava S. Sex differences in lipid mediators derived from omega-3 fatty acids in older individuals with low-grade chronic inflammation. Prostaglandins Leukot Essent Fatty Acids. 2024;203:102655. doi:10.1016/j.plefa.2024.102655
Choi GY, Calder PC. The differential effects of eicosapentaenoic acid and docosahexaenoic acid on cardiovascular risk factors: an updated systematic review of randomized controlled trials. Front Nutr. 2024;11:1423228. doi:10.3389/fnut.2024.1423228
Follonier C, Rabassa G, Branca M, Carballo D, Koskinas K, et al. Eligibility for marine omega-3 fatty acid supplementation after acute coronary syndromes. Atheroscler Plus. 2024;58:1. doi:10.1016/j.athplu.2024.09.002
Koutsaliaris IK, Pantazi D, Tsouka AN, Argyropoulou O, Tellis CC, et al. Differential Effect of Omega-3 Fatty Acids on Platelet Inhibition by Antiplatelet Drugs In Vitro. Int J Mol Sci. 2024;25. doi:10.3390/ijms251810136
Ren Y, Chen B, Zhang H, Xu S. A cohort study reveals shared and distinct serum metabolic biomarkers for major adverse cardiovascular events in middle-aged and older adults. Geroscience. 2025. doi:10.1007/s11357-025-01544-6
Arghavani H, Bilodeau JF, Rudkowska I. Association Between Circulating Fatty Acids and Blood Pressure: A Review. Curr Nutr Rep. 2025;14:15. doi:10.1007/s13668-024-00602-3
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